Supplements
                Unsigned Heaven     Travel World     The Cheers News     Forum    



How body's 'reconnaissance unit' screens 'self' or 'foreign' cells

thecheers.org    2007-11-25 08:28:05    

Washington, Nov 25 : A new study has shown how the body continuously screens and inspects the identity of cells to determine whether they are 'self' or 'foreign.'
A new study has shown how the body continuously screens and inspects the identity of cells to determine whether they are 'self' or 'foreign.'

The study, led by Prof. Israel Pecht of the Weizmann Institute's Immunology Department, has revealed that how the body's 'reconnaissance unit' continuously screens and inspects identity.

White blood cells called T cells employ specialized receptors called TCRs (T-cell receptors) for cell identification.

TCRs bind to molecules present on all our body's cells that act as 'self-I.D. cards.' Small fragments of bodily components bound to grooves in these molecules provide additional confirmation that the cell is ours and intruder-free.

TCRs, when they examine these complexes (antigens), are able to spot foreign bits, even when one amino acid in the antigen is out of order, and can pick just one infected cell out of thousands of healthy ones, even when they harbour a previously unknown virus.

The researchers have in their study provided a first step-by-step understanding of the interaction process.

Using a method, which resolves the biological events at millisecond intervals, the team was able to show how TCR binding progresses through time.

The analysis found that binding of the TCR to the antigen takes place in two separate stages, confirming the widely held theory that the process is an 'induced fit': The original physical contact between the two molecules initiates the second step, in which conformational changes occur in the receptor as it moulds itself to fit the antigen shape.

Pecht said that the research might go a long way toward explaining a seeming paradox of long standing: How T cells can be highly specific, able to precisely identify a particular protein structure, and yet able to bind to a very wide variety of protein molecules.

The findings might lead to deeper insights into the immune system and its function, and could yield new directions in pharmaceutical and medical research.

The study is published in the Proceedings of the National Academy of Sciences (PNAS). (ANI)
© 2007 ANI

Click for more News about Tech

TAGS: Tech   

The Cheers NEWS is looking for new local reporters


more
New rubber may soon see face masks that change shape to fit any face

It won't be long before there will be a face mask that may change its shape to fit any user, or a lens that does the same, for scientists have developed a new class of shape-memory rubber, that can be stretched to a new shape and regain its original shape when heated.

Google algorithm works very much like the human brain

A psychologist at the University of California, Berkeley, says that human memory studies may be improved by examining the tricks employed by online search engines and vice versa.

Technology upgradation vital to compete in global markets, says Kamal Nath
11.Dec 2007
Union Minister of Commerce and Industry Kamal Nath t...read

Now, a humanoid robot that is no pushover
7.Dec 2007
Japanese researchers have developed a humanoid robo...read

ISRO denies shelving of spy satellite launch under US pressure
4.Dec 2007
The Indian Space Research Organisation (ISRO) has rebutted reports appearing in...read



China to launch its first Mars probe in 2009

New technique creates adult image of girl missing for 26 years

Aussies more comfortable with their virtual personas rather than their true selves

Robot teddy to help sick kids

Scientists develop new multi purpose receiver





The Cheers magazine: About us | Contact us | The Cheers Story | Advertising
Work with The Cheers: Writers guide | Write for us | Writer application | Reporter application 
The Cheers:Terms and conditions | Privacy policy | Sponsoring | Sitemap
Sister sites: Tech Blog |  Best Auto Zine | Travel destinations by weather | Okai - critical commentary | Stock trading game | Wifi hotspots and wireless laptops | The Daily Bonk | Best Poker Zine | Business thoughts | Political commentary | Most expensive things | World News in ShortTop 10 listsPolitically incorrect blog
Listen: Online radio station
Travel World: World travel locations
Travel: Travel blogs | Travel destinations | Hotel reviews | Beer around the world
Watch: Watch series online
Trade: The Stock game | Trading competitions | Trading education
Entertainment Blogs
Entertainment blog
Copyright © 2004-2012 The Cheers magazine / How body\'s \'reconnaissance unit\' screens \'self\' or \'foreign\' cells





web stats